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Article

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

Nature genetics - 1 Feb 2017

Lee James C, Biasci Daniele, Roberts Rebecca, Gearry Richard B, Mansfield John C, Ahmad Tariq, Prescott Natalie J, Satsangi Jack, Wilson David C, Jostins Luke, Anderson Carl A, Traherne James A, Lyons Paul A, Parkes Miles, Smith Kenneth G C

Abstract excerpt

For most immune-mediated diseases, the main determinant of patient well-being is not the diagnosis itself but instead the course that the disease takes over time (prognosis). Prognosis may vary substantially between patients for reasons that are poorly understood. Familial studies support a genetic contribution to prognosis, but little evidence has been found for a proposed association between prognosis and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28067912
DOI: 10.1038/ng.3755
PMCID: PMC5730041

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