Article
Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease.
Circulation. Cardiovascular genetics - 1 Aug 2010
Liu Hui, El Zein Loubna, Kruse Martin, Guinamard Romain, Beckmann Alf, Bozio André, Kurtbay Güven, Mégarbané André, Ohmert Iris, Blaysat Gérard, Villain Elisabeth, Pongs Olaf, Bouvagnet Patrice
Abstract excerpt
BACKGROUND: Isolated cardiac conduction block is a relatively common condition in young and elderly populations. Genetic predisposing factors have long been suspected because of numerous familial case reports. Deciphering genetic predisposing factors of conduction blocks may give a hint at stratifying conduction block carriers in a more efficient way. METHODS AND RESULTS: One Lebanese family and 2 French families...
Topics
- Animals
- CHO Cells
- COS Cells
- Cardiac Conduction System Disease
- Cells, Cultured
- Chlorocebus aethiops
- Cricetinae
- Cricetulus
- Family
- Female
- Genes, Dominant
- Genetic Linkage
- Heart Block