Article
The lack of association between four point mutations in the promoter region of the toll-like 4 receptor gene and myocardial infarction.
Thrombosis research - 1 Jan 2007
De Staercke Christine, Lally Cathy, Austin Harland, Winston Carla, Dowling Nicole, Williams Byron, Hooper W Craig
Abstract excerpt
The toll-like receptor 4 gene product (TLR4) has been implicated in the pathogen recognition response mechanism because it plays a central role in the transcriptional activation of the host defense system. Activation of TLR4 initiates an intracellular signaling cascade, via the adapter protein MyD88 (myeloid differentiation factor 88), which leads to the activation of NF-kappaB transcriptional factor, and...
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