Article
UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients.
Therapeutic drug monitoring - 1 Dec 2012
Fukuda Tsuyoshi, Goebel Jens, Cox Shareen, Maseck Denise, Zhang Kejian, Sherbotie Joseph R, Ellis Eileen N, James Laura P, Ward Robert M, Vinks Alexander A
Abstract excerpt
BACKGROUND: Mycophenolic acid (MPA) exposure in pediatric patients with kidney transplant receiving body surface area (BSA)-based dosing exhibits large variability. Several genetic variants in glucuronosyltransferases (UGTs) and of multidrug resistance-associated protein 2 (MRP2) have independently been suggested to predict MPA exposure in adult patients with varying results. Here, the combined contribution of...
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