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Loss of function ABCG2 c.421C>A (rs2231142) polymorphism increases steady-state exposure to mycophenolic acid in stable renal transplant recipients: exploratory matched cohort study

2022-11-16

Abstract excerpt

<title>Abstract</title> <p><italic>Introduction.</italic> Polymorphism <italic>ABCG2 c.421C > A</italic> (rs2231142) results in a reduced activity of the important drug efflux transporter breast cancer resistance protein (BCRP/ABCG2). One study suggested that it may affect enterohepatic recirculation of mycophenolic acid (MPA). We evaluated the effect rs2231142 on steady-state exposure to MPA in renal transplant...

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Literature Corpus work
c41d6b29-7f6c-540b-8191-b383d2a0c605
DOI
10.21203/rs.3.rs-2247771/v1
Open publication

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Loss of function ABCG2 c.421C&gt;A (rs2231142) polymorphism increases steady-state exposure to mycophenolic acid in stable renal transplant recipients: exploratory matched cohort studyDOI 10.21203/rs.3.rs-2247771/v1
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