Article
Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle.
British journal of pharmacology - 1 Oct 2011
Roscioni Sara S, Prins Alwin G, Elzinga Carolina R S, Menzen Mark H, Dekkers Bart G J, Halayko Andrew J, Meurs Herman, Maarsingh Harm, Schmidt Martina
Abstract excerpt
BACKGROUND AND PURPOSE: Platelet-derived growth factor (PDGF) modulates the airway smooth muscle (ASM) 'contractile' phenotype to a more 'proliferative' phenotype, resulting in increased proliferation and reduced contractility. Such phenotypic modulation may contribute to airway remodelling in asthma. We have previously shown that the cAMP effector molecules, protein kinase A (PKA) and the exchange protein...
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