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Article

Store-operated Ca2+ entry contributes to the ASM phenotype transition in asthma.

Experimental lung research - 1 Jan 2025

Ni Hangqi, Li Ting, Chen Junjun, Wei Yuying, Xia Mengling, Wang Qing

Abstract excerpt

AIM OF THE STUDY: Phenotype modulation of airway smooth muscle cells (ASMC), characterized by a shift toward a more proliferative and synthetic phenotype from contractile cells, plays a crucial role in airway remodeling in asthma. STIM1 and Orai1, key components of store-operated Ca2+ entry (SOCE), have been demonstrated to enhance ASMC proliferation and migration. This study investigated the impact of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred BALB C

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Source

Identifiers

PMID: 40205756
DOI: 10.1080/01902148.2025.2486951

Genes

STIM1
MMP2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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