Article
Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma.
The European respiratory journal - 1 Jul 2000
Hirst S J, Walker T R, Chilvers E R
Abstract excerpt
Chronic persistent asthma is characterized by poorly reversible airflow obstruction and airways inflammation and remodelling. Histopathological studies of airways removed at post mortem from patients with severe asthma reveal marked inflammatory and architectural changes associated with airway wall thickening. Increased airway smooth muscle content, occurring as a result of hyperplastic and/or hypertrophic...
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