Article
The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2008
Yokoyama Utako, Patel Hemal H, Lai N Chin, Aroonsakool Nakon, Roth David M, Insel Paul A
Abstract excerpt
Scar formation occurs during the late stages of the inflammatory response but, when excessive, produces fibrosis that can lead to functional and structural damage of tissues. Here, we show that the profibrogenic agonist, transforming growth factor beta1, transcriptionally decreases expression of Exchange protein activated by cAMP 1 (Epac1) in fibroblasts/fibroblast-like cells from multiple tissues (i.e., cardiac,...
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