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Article

Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.

Cancer - 1 Apr 2011

Baba Yoshifumi, Nosho Katsuhiko, Shima Kaori, Hayashi Marika, Meyerhardt Jeffrey A, Chan Andrew T, Giovannucci Edward, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BACKGROUND: AKT (AKT1, AKT2, and AKT3) was a downstream effector of phosphatidylinositide-3-kinase (PI3K) and played crucial roles in protein synthesis, cellular metabolism, survival, and proliferation. The PI3K/AKT pathway was commonly activated in human cancers and was recognized as a potential target for anticancer therapy. Nonetheless, clinical, molecular, or prognostic features of AKT-activated colon cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21425139
DOI: 10.1002/cncr.25630
PMCID: PMC3092033

Genes

AKT1
AKT2
AKT3
BRAF
ESR1
FASN
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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