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Article

Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer.

British journal of cancer - 15 Apr 2014

Malinowsky K, Nitsche U, Janssen K-P, Bader F G, Späth C, Drecoll E, Keller G, Höfler H, Slotta-Huspenina J, Becker K-F

Abstract excerpt

BACKGROUND: Patients with UICC/AJCC stage II colon cancer have a high 5-year overall survival rate after surgery. Nevertheless, a significant subgroup of patients develops tumour recurrence. Currently, there are no clinically established biomarkers available to identify this patient group. We applied reverse-phase protein arrays (RPPA) for phosphatidylinositide-3-kinase pathway activation mapping to stratify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24619078
DOI: 10.1038/bjc.2014.100
PMCID: PMC3992486

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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