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Article

AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants.

Molecular cancer research : MCR - 1 Jun 2015

Hechtman Jaclyn F, Sadowska Justyna, Huse Jason T, Borsu Laetitia, Yaeger Rona, Shia Jinru, Vakiani Efsevia, Ladanyi Marc, Arcila Maria E

Abstract excerpt

UNLABELLED: The PI3K/AKT/mTOR pathway is activated through multiple mechanisms in colorectal carcinoma. Here, the clinicopathologic and molecular features of AKT1 E17K-mutated colorectal carcinoma in comparison with PIK3CA-mutated colorectal carcinoma are described in detail. Interestingly, in comparison with PIK3CA mutants, AKT1 E17K was significantly associated with mucinous morphology and concurrent BRAF V600E...

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Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microsatellite Instability

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 25714871
DOI: 10.1158/1541-7786.MCR-15-0062-T
PMCID: PMC4978128

Genes

AKT1
BRAF
EGFR
KRAS
NRAS
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants.PMID 25714871Read ↗

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