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The vacuolar shapes of ageing: From function to morphology

21 Feb 2019

Abstract excerpt

Cellular ageing results in accumulating damage to various macromolecules and the progressive decline of organelle function. Yeast vacuoles as well as their counterpart in higher eukaryotes, the lysosomes, emerge as central organelles in lifespan determination. These acidic organelles integrate enzymatic breakdown and recycling of cellular waste with nutrient sensing, storage, signalling and mobilization....

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PMID: 30796938
DOI: 10.1016/j.bbamcr.2019.02.011

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