Article
Candida albicans' inorganic phosphate transport and evolutionary adaptation to phosphate scarcity.
PLoS genetics - 1 Aug 2024
Acosta-Zaldívar Maikel, Qi Wanjun, Mishra Abhishek, Roy Udita, King William R, Li Yuping, Patton-Vogt Jana, Anderson Matthew Z, Köhler Julia R
Abstract excerpt
Phosphorus is essential in all cells' structural, metabolic and regulatory functions. For fungal cells that import inorganic phosphate (Pi) up a steep concentration gradient, surface Pi transporters are critical capacitators of growth. Fungi must deploy Pi transporters that enable optimal Pi uptake in pH and Pi concentration ranges prevalent in their environments. Single, triple and quadruple mutants were used to...
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