Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2011

Siggs Owen M, Schnabl Bernd, Webb Bill, Beutler Bruce

Abstract excerpt

Transporters at the hepatic canalicular membrane are essential for the formation of bile and the prevention of cholestatic liver disease. One such example is ATP8B1, a P4-type ATPase disrupted in three inherited forms of intrahepatic cholestasis. Mutation of the X-linked mouse gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Diseases, X-Linked
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholestasis, Intrahepatic

Share to Genes, X-Linked

Share to Lymphopenia

Share to Mice, Mutant Strains

Share to Mitochondrial Proton-Translocating ATPases

Share to Molecular Chaperones

Source

Open in PubMed Open full text

Identifiers

PMID: 21518881
DOI: 10.1073/pnas.1104631108
PMCID: PMC3093471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.PMID 21518881Read ↗

Impaired Hepatic Uptake by Organic Anion-Transporting Polypeptides Is Associated with Hyperbilirubinemia and Hypercholanemia in Atp11c Mutant Mice.Semantic proximity Read ↗

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.Semantic proximity Read ↗

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical ImplicationsSemantic proximity Read ↗

Canalicular ABC transporters and liver disease.Semantic proximity Read ↗

Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms.Semantic proximity Read ↗

Mammalian ABC Transporters in Health and DiseaseSemantic proximity Read ↗

Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletionSemantic proximity Read ↗

ABCB4 Mutations in Adults Cause a Spectrum Cholestatic Disorder Histologically Distinct from Other Biliary Disease.Semantic proximity Read ↗

A Comprehensive Review of Progressive Familial Intrahepatic Cholestasis (PFIC): Genetic Disorders of Hepatocanalicular TransportersSemantic proximity Read ↗

Update on progressive familial intrahepatic cholestasis.Semantic proximity Read ↗

Cholestasis: the ABCs of cellular mechanisms for impaired bile secretion--transporters and genes.Semantic proximity Read ↗

Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.