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Article

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype.

Cell reports - 20 Sept 2016

Luc Sidinh, Huang Jialiang, McEldoon Jennifer L, Somuncular Ece, Li Dan, Rhodes Claire, Mamoor Shahan, Hou Serena, Xu Jian, Orkin Stuart H

Abstract excerpt

B cell CLL/lymphoma 11A (BCL11A) is a transcription factor and regulator of hemoglobin switching that has emerged as a promising therapeutic target for sickle cell disease and thalassemia. In the hematopoietic system, BCL11A is required for B lymphopoiesis, yet its role in other hematopoietic cells, especially hematopoietic stem cells (HSCs) remains elusive. The extensive expression of BCL11A in hematopoiesis...

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Identifiers

PMID: 27653684
DOI: 10.1016/j.celrep.2016.08.064
PMCID: PMC5054719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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