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Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice

30 Jan 2013

Abstract excerpt

B-cell lymphoma 11A (BCL11A) downregulation in human primary adult erythroid progenitors results in elevated expression of fetal γ-globin. Recent reports showed that BCL11A expression is activated by KLF1, leading to γ-globin repression. To study regulation of erythropoiesis and globin expression by KLF1 and BCL11A in an in vivo model, we used mice carrying a human β-globin locus transgene with combinations of...

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PMID: 23361909
DOI: 10.1182/blood-2012-06-434530

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