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Article

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.

Oncogene - 25 May 2006

Metzler M, Forster A, Pannell R, Arends M J, Daser A, Lobato M N, Rabbitts T H

Abstract excerpt

MLL-AF4 fusion is the most common consequence of chromosomal translocations in infant leukaemia and is associated with a poor prognosis. MLL-AF4 is thought to be required in haematopoietic stem cells to elicit leukaemia and may be involved in tumour phenotype specification as it is only found in B-cell tumours in humans. We have employed the invertor conditional technology to create a model of MLL-AF4, in which a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16607274
DOI: 10.1038/sj.onc.1209636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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