Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of HLA class II alleles and CTLA-4 polymorphism with type 1 diabetes.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia - 1 Mar 2011

Ei Wafai Rana J, Chmaisse Hania Nakkash, Makki Rajaa F, Fakhoury Hana

Abstract excerpt

Type-1 diabetes mellitus (T1DM) is a progressive complex autoimmune disease in which combinations of environmental as well as genetic factors contribute to T-cell mediated destruction of insulin-secreting β-cells of the pancreas. HLA class II alleles on chromosome 6p21 [insulin dependent diabetes mellitus 1 (IDDM1)], especially DR and DQ, show strong association with T1DM. In addition, several studies have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arabs
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Lebanon

Source

Identifiers

PMID: 21422625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of HLA class II alleles and CTLA-4 polymorphism with type 1 diabetes.PMID 21422625Read ↗

Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania.Semantic proximity Read ↗

[Association between type 1 diabetes and polymorphism of the CTLA-4 gene in a Tunisian population].Semantic proximity Read ↗

Association of HLA-DRB1 and -DQ Alleles and Haplotypes with Type 1 Diabetes in Jordanians.Semantic proximity Read ↗

Increased and decreased relative risk for non-insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians.Semantic proximity Read ↗

Association of single-nucleotide polymorphisms in tumour necrosis factor and human leukocyte antigens genes with type 1 diabetes.Semantic proximity Read ↗

Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

Association of HLA-DRB1 and -DQB1 alleles with type 1 (autoimmune) diabetes in African Arabs: systematic review and meta-analysis.Semantic proximity Read ↗

CTLA-4 +49 A/G polymorphism is associated with predisposition to type 1 diabetes in Iranians.Semantic proximity Read ↗

The influence of the HLA-DRB, HLA-DQB and polymorphic positions of the HLA-DRβ1 and HLA-DQβ1 molecules on risk of Iranian type 1 diabetes mellitus patients.Semantic proximity Read ↗

HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study.Semantic proximity Read ↗

Association between the CTLA-4 +49A/G polymorphism and type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.