Article
[Association between type 1 diabetes and polymorphism of the CTLA-4 gene in a Tunisian population].
Pathologie-biologie - 1 Dec 2001
Kamoun Abid H, Hmida S, Smaoui N, Kaabi H, Abid A, Chaabouni H, Boukef K, Nagati K
Abstract excerpt
Susceptibility to type 1 diabetes mellitus is strongly associated with particular HLA class II alleles. However, non HLA genetic factors are likely to be required for the development of disease. The candidate genes include the cytotoxic T lymphocyte associated 4 (CTLA-4) located on chromosome 2q33 and designated (IDDM12), which encodes a cell surface negative signal T molecule providing for activation. We...
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