Article
Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: a meta-analysis.
Gene - 10 Mar 2013
Chen Zixian, Fei Min, Fu Da, Zhang Liang, Ma Yushui, Wang Yichao, Zhang Feng, Xia Qing, Wang Xiaofeng
Abstract excerpt
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is an important mediators of T-cell activation in autoimmune diseases. The association of polymorphisms of CTLA gene with type 1 diabetes (T1D) has widely been reported; however, the results are inconsistent. To obtain further insight into this topic, we performed a meta-analysis of 52 studies involving a total of 11,017 cases and 14,191 controls for 49A/G...
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