Article
CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia.
Haematologica - 1 Jun 2011
Haferlach Claudia, Bacher Ulrike, Kohlmann Alexander, Schindela Sonja, Alpermann Tamara, Kern Wolfgang, Schnittger Susanne, Haferlach Torsten
Abstract excerpt
BACKGROUND: Alterations of the short arm of chromosome 12 (12p) occur in various hematologic malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest. DESIGN AND METHODS: We selected seven patients with myeloid malignancies and small 12p deletions detected by fluorescence in situ hybridization encompassing only the region centromeric of ETV6 and further...
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