Article
13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia.
Leukemia - 1 Mar 2011
Parker H, Rose-Zerilli M J J, Parker A, Chaplin T, Wade R, Gardiner A, Griffiths M, Collins A, Young B D, Oscier D G, Strefford J C
Abstract excerpt
Historically, genes targeted by recurrent chromosomal deletions have been identified within the smallest genomic region shared in all patients, the minimally deleted region (MDR). However, deletions this small do not occur in all patients and are a simplification of the impact larger heterogeneous deletions have during carcinogenesis. We use the example of 13q14 deletions in chronic lymphocytic leukemia to show...
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