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Article

Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype.

BMC genomics - 11 Sept 2014

Feurstein Simone, Rücker Frank G, Bullinger Lars, Hofmann Winfried, Manukjan Georgi, Göhring Gudrun, Lehmann Ulrich, Heuser Michael, Ganser Arnold, Döhner Konstanze, Schlegelberger Brigitte, Steinemann Doris

Abstract excerpt

BACKGROUND: Acute myeloid leukemia with complex karyotype (CK-AML) is a distinct biological entity associated with a very poor outcome. Since complex karyotypes frequently contain deletions of the chromosomal region 12p13 encompassing the tumor suppressor genes ETV6 and CDKN1B, we aimed to unravel their modes of inactivation in CK-AML. RESULTS: To decipher deletions, mutations and methylation of ETV6 and CDKN1B,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to ETS Translocation Variant 6 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 25213837
DOI: 10.1186/1471-2164-15-784
PMCID: PMC4168160

Genes

ETV6
DUSP16
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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