CDKN2A/B alterations impair prognosis in adult BCR-ABL1-positive acute lymphoblastic leukemia patients.

doi:10.1158/1078-0432.CCR-11-1227

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

CDKN2A/B alterations impair prognosis in adult BCR-ABL1-positive acute lymphoblastic leukemia patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2011

Iacobucci Ilaria, Ferrari Anna, Lonetti Annalisa, Papayannidis Cristina, Paoloni Francesca, Trino Stefania, Storlazzi Clelia Tiziana, Ottaviani Emanuela, Cattina Federica, Impera Luciana, Abbenante Maria Chiara, Vignetti Marco, Vitale Antonella, Potenza Leonardo, Paolini Stefania, Soverini Simona, Pane Fabrizio, Luppi Mario, Foà Robin, Baccarani Michele, Martinelli Giovanni

Abstract excerpt

PURPOSE: The 9p21 locus, encoding three important tumor suppressors (p16/CDKN2A, p14/ARF, and p15/CDKN2B), is a major target of inactivation in the pathogenesis of many human tumors. PATIENTS AND METHODS: To explore, at high resolution, the frequency and size of alterations affecting this locus in adult BCR-ABL1-positive acute lymphoblastic leukemia (ALL) and to investigate their prognostic value, 112 patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Fusion Proteins, bcr-abl

Share to Oligonucleotide Array Sequence Analysis

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Prognosis

Share to Protein-Tyrosine Kinases

Share to Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 22134481
DOI: 10.1158/1078-0432.CCR-11-1227

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDKN2A/B alterations impair prognosis in adult BCR-ABL1-positive acute lymphoblastic leukemia patients.PMID 22134481Read ↗

Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Biallelic loss ofCDKN2Ais associated with poor response to treatment in pediatric acute lymphoblastic leukemiaSemantic proximity Read ↗

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).Semantic proximity Read ↗

Molecular inversion probes reveal patterns of 9p21 deletion and copy number aberrations in childhood leukemia.Semantic proximity Read ↗

The Yin and Yang-Like Clinical Implications of the CDKN2A/ARF/CDKN2B Gene Cluster in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

The role of CDKN2A/B deletions in pediatric acute lymphoblastic leukemiaSemantic proximity Read ↗

SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia.Semantic proximity Read ↗

Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL.Semantic proximity Read ↗

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011.Semantic proximity Read ↗

The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21Semantic proximity Read ↗

Focal 9p instability in hematologic neoplasias revealed by comparative genomic hybridization and single-nucleotide polymorphism microarray analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.