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Article

Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes.

Cardiovascular research - 15 Jul 2011

Tian Chengju, Shao Chun Hong, Moore Caronda J, Kutty Shelby, Walseth Timothy, DeSouza Cyrus, Bidasee Keshore R

Abstract excerpt

AIMS: Ventricular myocytes isolated from hearts of streptozotocin (STZ)-diabetic rats exhibit increased spontaneous Ca(2+) release. Studies attribute this defect to an enhancement in activity of type 2 ryanodine receptor (RyR2). To date, underlying reasons for RyR2 dysregulation remain undefined. This study assesses whether the responsiveness of RyR2 following stimulation by intrinsic ligands is being altered...

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Share to Calcium Signaling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21421556
DOI: 10.1093/cvr/cvr076
PMCID: PMC3125072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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