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Article

Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2002

Vetter Roland, Rehfeld Uwe, Reissfelder Christoph, Weiss Wolfgang, Wagner Kay-Dietrich, Günther Joachim, Hammes Annette, Tschöpe Carsten, Dillmann Wolfgang, Paul Martin

Abstract excerpt

Slowed relaxation in diabetic cardiomyopathy (CM) is partially related to diminished expression of the sarcoplasmic reticulum (SR) Ca2+-ATPase SERCA2a. To evaluate the impact of SERCA2a overexpression on SR Ca2+ handling in diabetic CM, we 1) generated transgenic rats harboring a human cytomegalovirus enhancer/chicken beta-actin promotor-controlled rat SERCA2 transgene (SERCA2-TGR), 2) characterized their SR...

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Share to Animals, Genetically Modified
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

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Identifiers

PMID: 12206992
DOI: 10.1096/fj.01-1019fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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