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Article

Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a.

PloS one - 31 Jul 2009

Karakikes Ioannis, Kim Maengjo, Hadri Lahouaria, Sakata Susumu, Sun Yezhou, Zhang Weijia, Chemaly Elie R, Hajjar Roger J, Lebeche Djamel

Abstract excerpt

BACKGROUND/AIM: Diabetes-associated myocardial dysfunction results in altered gene expression in the heart. We aimed to investigate the changes in gene expression profiles accompanying diabetes-induced cardiomyopathy and its phenotypic rescue by restoration of SERCA2a expression. METHODS/RESULTS: Using the Otsuka Long-Evans Tokushima Fatty rat model of type 2 diabetes and the Agilent rat microarray chip, we...

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Identifiers

PMID: 19649297
DOI: 10.1371/journal.pone.0006474
PMCID: PMC2714457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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