Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis.

Journal of affective disorders - 1 Jul 2011

Carver Charles S, Johnson Sheri L, Joormann Jutta, Lemoult Joelle, Cuccaro Michael L

Abstract excerpt

The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MDD was diagnosed by Structured Clinical Interview for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diagnostic and Statistical Manual of Mental Disorders

Share to Epistasis, Genetic

Share to Genetic Association Studies

Share to Life Change Events

Share to Serotonin Plasma Membrane Transport Proteins

Share to Young Adult

Source

Identifiers

PMID: 21420735
DOI: 10.1016/j.jad.2011.02.001

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis.PMID 21420735Read ↗

The interaction between child maltreatment, adult stressful life events and the 5-HTTLPR in major depression.Semantic proximity Read ↗

Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults.Semantic proximity Read ↗

Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder.Semantic proximity Read ↗

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.Semantic proximity Read ↗

The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication.Semantic proximity Read ↗

Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search.Semantic proximity Read ↗

Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.Semantic proximity Read ↗

Interaction between childhood adversity, brain-derived neurotrophic factor val/met and serotonin transporter promoter polymorphism on depression: the TRAILS study.Semantic proximity Read ↗

Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample.Semantic proximity Read ↗

No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: results from two community surveys.Semantic proximity Read ↗

The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study.Semantic proximity Read ↗

Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.