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Article

The interaction between child maltreatment, adult stressful life events and the 5-HTTLPR in major depression.

Journal of psychiatric research - 1 Aug 2013

Power Robert A, Lecky-Thompson Lucy, Fisher Helen L, Cohen-Woods Sarah, Hosang Georgina M, Uher Rudolf, Powell-Smith Georgia, Keers Robert, Tropeano Maria, Korszun Ania, Jones Lisa, Jones Ian, Owen Michael J, Craddock Nick, Craig Ian W, Farmer Anne E, McGuffin Peter

Abstract excerpt

Both childhood maltreatment and adult stressful life events are established risk factors for the onset of depression in adulthood. However, the interaction between them can be viewed through two conflicting frameworks. Under a mismatch hypothesis stressful childhoods allow 'adaptive programming' for a stressful adulthood and so can be protective. Only when childhood and adulthood do not match is there a risk of...

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Identifiers

PMID: 23618376
DOI: 10.1016/j.jpsychires.2013.03.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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