The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.

doi:10.1053/j.gastro.2011.03.011

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Article

The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.

Gastroenterology - 1 Jun 2011

Kilpatrick Lisa A, Labus Jennifer S, Coveleskie Kristen, Hammer Christian, Rappold Gudrun, Tillisch Kirsten, Bueller Joshua A, Suyenobu Brandall, Jarcho Johana M, McRoberts Jim A, Niesler Beate, Mayer Emeran A

Abstract excerpt

BACKGROUND & AIMS: 5-Hydroxytryptamine (5-HT)3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. Their therapeutic effects are related, in part, to reducing amygdala engagement during expected visceral pain. A single nucleotide polymorphism in HTR3A, c.-42C>T;(C178T; rs1062613), is associated with altered reactivity of the amygdala...

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PMID: 21420406
DOI: 10.1053/j.gastro.2011.03.011
PMCID: PMC3757951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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