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Article

Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia.

BMC medical genetics - 20 Oct 2011

Mujakovic Suhreta, ter Linde José Jm, de Wit Niek J, van Marrewijk Corine J, Fransen Gerdine Aj, Onland-Moret N Charlotte, Laheij Robert Jf, Muris Jean Wm, Grobbee Diederick E, Samsom Melvin, Jansen Jan Bmj, Knottnerus André, Numans Mattijs E

Abstract excerpt

BACKGROUND: The association between anxiety and depression related traits and dyspepsia may reflect a common genetic predisposition. Furthermore, genetic factors may contribute to the risk of having increased visceral sensitivity, which has been implicated in dyspeptic symptom generation. Serotonin (5-HT) modulates visceral sensitivity by its action on 5-HT3 receptors. Interestingly, a functional polymorphism in...

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Identifiers

PMID: 22014438
DOI: 10.1186/1471-2350-12-140
PMCID: PMC3213216

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HTT

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