Article
Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin.
The EMBO journal - 3 Oct 2007
Han Li, Stope Matthias B, de Jesús Maider López, Oude Weernink Paschal A, Urban Martina, Wieland Thomas, Rosskopf Dieter, Mizuno Kensaku, Jakobs Karl H, Schmidt Martina
Abstract excerpt
The activity state of cofilin, which controls actin dynamics, is driven by a phosphorylation-dephosphorylation cycle. Phosphorylation of cofilin by LIM-kinases results in its inactivation, a process supported by 14-3-3zeta and reversed by dephosphorylation by slingshot phosphatases. Here we report on a novel cellular function for the phosphorylation-dephosphorylation cycle of cofilin. We demonstrate that...
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