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Article

Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains

1 Dec 2010

Abstract excerpt

The formin mDia2 mediates the formation of lamellipodia and filopodia during cell locomotion. The subcellular localization of activated mDia2 depends on interactions with actin filaments and the plasma membrane. We investigated the poorly understood mechanism of plasma membrane targeting of mDia2 and found that the entire N-terminal region of mDia2 preceding the actin-polymerizing formin homology domains 1 and 2...

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PMID: 21119010
DOI: 10.1091/mbc.e10-03-0256

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