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Article

A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation.

Molecular and cellular biology - 1 May 2010

Henkels Karen M, Peng Hong-Juan, Frondorf Kathleen, Gomez-Cambronero Julian

Abstract excerpt

We report here that the enzymatic activity of phospholipase D2 (PLD2) is regulated by phosphorylation-dephosphorylation. Phosphatase treatment of PLD2-overexpressing cells showed a biphasic nature of changes in activity that indicated the existence of "activator" and "inhibitory" sites. We identified three kinases capable of phosphorylating PLD2 in vitro-epidermal growth factor receptor (EGFR), JAK3, and Src...

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Source

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Identifiers

PMID: 20176813
DOI: 10.1128/MCB.01239-09
PMCID: PMC2863589

Genes

PLD2
EGFR
JAK3

Provenance

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