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Article

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

Human molecular genetics - 1 Sept 2015

Fernández-Nogales Marta, Hernández Félix, Miguez Andrés, Alberch Jordi, Ginés Silvia, Pérez-Navarro Esther, Lucas José J

Abstract excerpt

Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by brain atrophy particularly in striatum leading to personality changes, chorea and dementia. Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase in the crossroad of many signaling pathways that is highly pleiotropic as it phosphorylates more than hundred substrates including structural, metabolic, and signaling...

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Identifiers

PMID: 26082469
DOI: 10.1093/hmg/ddv224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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