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Article

Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival.

The Journal of biological chemistry - 9 Feb 2007

Liang Min-Huei, Chuang De-Maw

Abstract excerpt

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase consisting of two isoforms, alpha and beta. The activities of GSK-3 are regulated negatively by serine phosphorylation but positively by tyrosine phosphorylation. GSK-3 inactivation has been proposed as a mechanism to promote neuronal survival. We used GSK-3 isoform-specific small interfering RNAs, dominant-negative mutants, or pharmacological...

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Identifiers

PMID: 17148450
DOI: 10.1074/jbc.M605178200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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