Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of CYP3A5*3 on risk and prognosis in childhood acute lymphoblastic leukemia.

European journal of haematology - 1 Jun 2011

Borst Louise, Wallerek Sandra, Dalhoff Kim, Rasmussen Kirsten K, Wesenberg Finn, Wehner Peder S, Schmiegelow Kjeld

Abstract excerpt

OBJECTIVES: Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood; however, little is known of the molecular etiology and environmental exposures causing the disease. Cytochrome P450 3A5 (CYP3A5) plays a crucial role in the catalytic oxidation of endogenous metabolites and toxic substances, including chemotherapeutic agents. The aim of this study was to investigate the role of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP3A
Share to Denmark

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Pharmacogenetics

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Treatment Outcome

Source

Identifiers

PMID: 21418106
DOI: 10.1111/j.1600-0609.2011.01608.x

Genes

EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of CYP3A5*3 on risk and prognosis in childhood acute lymphoblastic leukemia.PMID 21418106Read ↗

CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome.Semantic proximity Read ↗

Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome.Semantic proximity Read ↗

CYP3A5 ∗ 3 genetic polymorphism is associated with childhood acute lymphoblastic leukemia risk: A meta-analysis.Semantic proximity Read ↗

Polymorphisms of drug-metabolizing enzymes and risk of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia.Semantic proximity Read ↗

Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Ancestry and pharmacogenetics of antileukemic drug toxicity.Semantic proximity Read ↗

Polygenic Pharmacogenomic Markers as Predictors of Toxicity Phenotypes in the Treatment of Acute Lymphoblastic Leukemia: A Single-Center Study.Semantic proximity Read ↗

[Expression of CYP3A5 mRNA in children with acute leukemia].Semantic proximity Read ↗

Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.