Article
In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia.
The pharmacogenomics journal - 1 Jun 2015
Gézsi A, Lautner-Csorba O, Erdélyi D J, Hullám G, Antal P, Semsei Á F, Kutszegi N, Hegyi M, Csordás K, Kovács G, Szalai C
Abstract excerpt
CYP3A4 has an important role in the metabolisms of many drugs used in acute lymphoblastic leukemia (ALL) therapy; still, there are practically no publications about the role of CYP3A4 polymorphisms in ALL pharmacogenomics. We genotyped eight common single-nucleotide polymorphisms (SNPs) in the CYP3A4 and CYP3A5 genes in 511 children with ALL and investigated whether they influenced the survival of the patients....
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