Article
Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia.
Oncology - 1 Jan 2007
Ulusoy Gulen, Adali Orhan, Tumer Tugba Boyunegmez, Sahin Gurses, Gozdasoglu Sevgi, Arinç Emel
Abstract excerpt
BACKGROUND/AIMS: The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP2E1 is a susceptible gene in this respect, especially for its capacity to bioactivate many...
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