Article
Ancestry and pharmacogenetics of antileukemic drug toxicity.
Blood - 15 May 2007
Kishi Shinji, Cheng Cheng, French Deborah, Pei Deqing, Das Soma, Cook Edwin H, Hijiya Nobuko, Rizzari Carmelo, Rosner Gary L, Frudakis Tony, Pui Ching-Hon, Evans William E, Relling Mary V
Abstract excerpt
Treatment-related toxicity in acute lymphoblastic leukemia (ALL) can not only be life threatening but may also affect relapse risk. In 240 patients, we determined whether toxicities were related to 16 polymorphisms in genes linked to the pharmacodynamics of ALL chemotherapy, adjusting for age, ra...
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