Article
[Expression of CYP3A5 mRNA in children with acute leukemia].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 1 Jul 2009
Huang Zhen, Chai Yi-Huan, Cen Jian-Nong, He Hai-Long, Li Jie
Abstract excerpt
OBJECTIVE: The cytochrome P450 subfamily IIIA5 (CYP3A5) gene is responsible for the metabolism of many clinically used anticancer agents. So far the studies on CYP3A5 gene has only been focused on the leukemia cell lines. This study examined the polymorphism of CYP3A5 and tried to find the possible relationship between CYP3A5 gene expression and treatment outcome or prognosis in children with acute leukemia....
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