Article
Effect of multidrug resistance-conferring mutations on the fitness and virulence of Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy - 1 Jun 2011
Abdelraouf Kamilia, Kabbara Samer, Ledesma Kimberly R, Poole Keith, Tam Vincent H
Abstract excerpt
BACKGROUND: Multidrug resistance has become a quandary in the treatment of bacterial infections. The effect of resistance mutations and the fitness cost on the pathogenicity of Pseudomonas aeruginosa is not well established. The objective of this study was to examine the impact of multidrug resistance on the fitness and virulence of P. aeruginosa. METHODS: Fourteen P. aeruginosa strains with various resistance...
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