Article
Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic-Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps.
mBio - 25 Jul 2017
Olivares Pacheco Jorge, Alvarez-Ortega Carolina, Alcalde Rico Manuel, Martínez José Luis
Abstract excerpt
It is generally assumed that the acquisition of antibiotic resistance is associated with a fitness cost. We have shown that overexpression of the MexEF-OprN efflux pump does not decrease the fitness of a resistant Pseudomonas aeruginosa strain compared to its wild-type counterpart. This lack of fitness cost was associated with a metabolic rewiring that includes increased expression of the anaerobic nitrate...
Topics
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Drug Resistance, Multiple, Bacterial
- Electron Transport
- Genetic Fitness
- Membrane Proteins
- Membrane Transport Proteins
- Microbial Sensitivity Tests
- Mutation
- Nitrates
- Pseudomonas aeruginosa