Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic compensation of fitness costs associated with overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Jul 2014

Olivares Jorge, Álvarez-Ortega Carolina, Martinez José Luis

Abstract excerpt

The acquisition of antibiotic resistance has been associated with a possible nonspecific, metabolic burden that is reflected in decreased fitness among resistant bacteria. We have recently demonstrated that overexpression of the MexEF-OprN multidrug efflux pump does not produce a metabolic burden when measured by classical competitions tests but rather leads to a number of changes in the organism's physiology....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaerobiosis
Share to Bacterial Outer Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport

Share to Genetic Fitness

Share to Nitrates

Share to Nitric Oxide

Share to Oxygen Consumption

Share to Pseudomonas aeruginosa

Source

Open in PubMed Open full text

Identifiers

PMID: 24777101
DOI: 10.1128/AAC.00121-14
PMCID: PMC4068598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic compensation of fitness costs associated with overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa.PMID 24777101Read ↗

Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic-Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps.Semantic proximity Read ↗

Evidence of MexT-independent overexpression of MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa in presence of metabolic stress.Semantic proximity Read ↗

Mutation of nfxB causes global changes in the physiology and metabolism of Pseudomonas aeruginosa.Semantic proximity Read ↗

Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutants.Semantic proximity Read ↗

Reduction of the fitness cost of antibiotic resistance caused by chromosomal mutations under poor nutrient conditions.Semantic proximity Read ↗

Analysis of fitness costs associated with metronidazole and amoxicillin resistance in Helicobacter pylori.Semantic proximity Read ↗

Restoration of Nitrate Respiration in Pseudomonas aeruginosa under Growth Limitations.Semantic proximity Read ↗

Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway.Semantic proximity Read ↗

Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa.Semantic proximity Read ↗

The multidrug resistance efflux pump MexCD-OprJ is a switcher of the <i>Pseudomonas aeruginosa</i> quorum sensing responseSemantic proximity Read ↗

Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance.Semantic proximity Read ↗

Effect of multidrug resistance-conferring mutations on the fitness and virulence of Pseudomonas aeruginosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.