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Article

Benefit of having multiple ampD genes for acquiring beta-lactam resistance without losing fitness and virulence in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Oct 2008

Moya Bartolomé, Juan Carlos, Albertí Sebastián, Pérez José L, Oliver Antonio

Abstract excerpt

The inactivation of ampD in Pseudomonas aeruginosa leads to a partially derepressed phenotype, characterized by a moderately high level basal ampC expression that is still further inducible, due to the presence of two additional ampD genes in this species (ampDh2 and ampDh3). The sequential inactivation of the three ampD genes was shown to lead to a stepwise upregulation of ampC expression, reaching full...

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Identifiers

PMID: 18644952
DOI: 10.1128/AAC.00172-08
PMCID: PMC2565882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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