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Article

Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.

Brain research - 30 Jul 2008

Cotel Marie-Caroline, Bayer Thomas A, Wirths Oliver

Abstract excerpt

Loss of neurons in the hippocampus and other brain regions is, besides the occurrence of plaques and tangles, a neuropathological feature of Alzheimer's disease (AD). In recent years a plethora of transgenic mouse models overexpressing mutant amyloid precursor protein (APP) has been developed, wh...

Topics

Age Factors
Aging
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Analysis of Variance
Animals
Cell Death
Dentate Gyrus
Humans
Mice
Mice, Transgenic
Mutation
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Presenilin-1

Stereotaxic Techniques

Source

Identifiers

PMID: 18585693
DOI: 10.1016/j.brainres.2008.05.052

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18585693-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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