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Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice

26 Aug 2009

Abstract excerpt

Neurodegenerative diseases are characterized by 'hot spots' of degeneration. The regions of primary vulnerability vary between different neurodegenerative diseases. Within these regions, some neurons are lost whereas others that are morphologically indiscriminate survive. The enigma of this selective vulnerability is tightly linked to two fundamental problems in the neurosciences. First, it is not understood how...

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PMID: 19584440
DOI: 10.3233/jad-2009-1143

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