Article
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.
Neurobiology of disease - 1 Mar 2003
Rutten Bart P F, Wirths Oliver, Van de Berg Wilma D J, Lichtenthaler Stefan F, Vehoff Jochen, Steinbusch Harry W M, Korr Hubert, Beyreuther Konrad, Multhaup Gerd, Bayer Thomas A, Schmitz Christoph
Abstract excerpt
Previous studies in the literature have resulted in conflicting reports on the potential neurotoxicity of the beta-cleaved Alzheimer's disease C-terminal fragment (beta-CTF) of beta-amyloid precursor protein in vivo. To readdress this question by rigorous quantitative methods, we analyzed transgenic mice expressing human beta-CTF with the I45F mutation (SPA4CT) under control of the prion protein promoter by...
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