Article
Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers.
International journal of cancer - 1 Apr 2013
Talseth-Palmer Bente A, Wijnen Juul T, Brenne Ingvild S, Jagmohan-Changur Shantie, Barker Daniel, Ashton Katie A, Tops Carli M, Evans Tiffany-Jane, McPhillips Mary, Groombridge Claire, Suchy Janina, Kurzawski Grzegorz, Spigelman Allan, Møller Pål, Morreau Hans M, Van Wezel Tom, Lubinski Jan, Vasen Hans F A, Scott Rodney J
Abstract excerpt
Two colorectal cancer (CRC) susceptibility loci have been found to be significantly associated with an increased risk of CRC in Dutch Lynch syndrome (LS) patients. Recently, in a combined study of Australian and Polish LS patients, only MLH1 mutation carriers were found to be at increased risk of disease. A combined analysis of the three data-sets was performed to better define this association. This cohort-study...
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